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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HAND2
All Species:
14.85
Human Site:
S63
Identified Species:
29.7
UniProt:
P61296
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61296
NP_068808.1
217
23666
S63
P
D
Y
S
M
A
L
S
Y
S
P
E
Y
A
S
Chimpanzee
Pan troglodytes
XP_518050
215
23636
P62
D
F
P
A
G
G
P
P
P
A
A
A
A
A
A
Rhesus Macaque
Macaca mulatta
XP_001085733
186
20831
P56
G
H
P
E
M
S
P
P
D
Y
S
M
A
L
S
Dog
Lupus familis
XP_849189
259
28533
S105
L
D
Y
S
M
A
L
S
Y
S
P
E
Y
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q64279
216
23787
P62
D
F
P
A
G
G
P
P
P
T
T
A
V
A
A
Rat
Rattus norvegicus
P61295
217
23647
S63
P
D
Y
S
M
A
L
S
Y
S
P
E
Y
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508110
232
25238
A81
D
F
P
G
G
P
A
A
A
A
A
A
Y
G
P
Chicken
Gallus gallus
Q90690
216
24388
S62
P
D
Y
S
M
A
L
S
Y
S
P
E
Y
A
N
Frog
Xenopus laevis
P57101
210
23235
Y63
A
P
S
Y
S
P
E
Y
A
N
G
A
A
G
L
Zebra Danio
Brachydanio rerio
P57102
208
23149
S62
P
S
Y
S
P
E
Y
S
T
G
A
P
G
L
D
Tiger Blowfish
Takifugu rubipres
Q90YI8
371
40876
A141
P
P
Q
Q
R
D
D
A
R
M
V
Q
L
S
P
Fruit Fly
Dros. melanogaster
NP_609370
174
20059
L46
Q
I
Y
N
T
S
H
L
G
Y
V
P
T
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.9
85.7
71
N.A.
54.8
100
N.A.
44.8
87
90.7
83.4
21.2
37.7
N.A.
N.A.
N.A.
Protein Similarity:
100
64.5
85.7
72.9
N.A.
63.1
100
N.A.
56
88.9
92.6
89.4
31.5
49.3
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
13.3
93.3
N.A.
6.6
100
N.A.
6.6
93.3
0
26.6
6.6
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
20
93.3
N.A.
26.6
100
N.A.
20
100
6.6
26.6
26.6
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
17
0
34
9
17
17
17
25
34
25
50
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
25
34
0
0
0
9
9
0
9
0
0
0
0
0
9
% D
% Glu:
0
0
0
9
0
9
9
0
0
0
0
34
0
0
0
% E
% Phe:
0
25
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
9
25
17
0
0
9
9
9
0
9
17
0
% G
% His:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
0
0
0
0
0
34
9
0
0
0
0
9
17
9
% L
% Met:
0
0
0
0
42
0
0
0
0
9
0
9
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
0
0
9
0
0
0
0
17
% N
% Pro:
42
17
34
0
9
17
25
25
17
0
34
17
0
0
17
% P
% Gln:
9
0
9
9
0
0
0
0
0
0
0
9
0
0
0
% Q
% Arg:
0
0
0
0
9
0
0
0
9
0
0
0
0
0
0
% R
% Ser:
0
9
9
42
9
17
0
42
0
34
9
0
0
17
34
% S
% Thr:
0
0
0
0
9
0
0
0
9
9
9
0
9
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
17
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
50
9
0
0
9
9
34
17
0
0
42
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _